• Acute carbon monoxide intoxication
• Decompression illness
• Gas embolism
• Gas gangrene
• Acute traumatic peripheral ischemia
• Crush injuries and suturing of severed limbs
• Progressive necrotizing infections
• Acute peripheral arterial insufficiency
• Preparation and preservation of compromised skin grafts
• Chronic refractory osteomyelitis, unresponsive to conventional medical and surgical management
• Osteoradionecrosis as an adjunct to conventional treatment
• Soft tissue radionecrosis as an adjunct to conventional treatment
• Cyanide poisoning
• Actinomycosis, only as an adjunct to conventional therapy when the disease process is refractory to antibiotics and surgical treatment
• Diabetic wounds of the lower extremities if all of these apply:
1. You have Type 1 or Type 2 diabetes and have a lower extremity wound that’s due to diabetes.
2. You have a wound classified as Wagner grade III or higher.
3. You’ve failed an adequate course of standard wound therapy
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